Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition.

@article{Gervin2016CellTS,
  title={Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition.},
  author={Kristina Gervin and Christian M Page and Hans Christian Dalsbotten Aass and Michelle Jansen and Heidi Elisabeth Fjeldstad and Bettina K. Andreassen and Liesbeth Duijts and Joyce B. J. van Meurs and Menno C van Zelm and Vincent W. V. Jaddoe and Hedvig Nordeng and Gunn Peggy Knudsen and Per M. Magnus and Wenche Nystad and Anne Cathrine Staff and Janine F. Felix and Robert Lyle},
  journal={Epigenetics},
  year={2016},
  volume={11 9},
  pages={690-698}
}
Epigenome-wide association studies of prenatal exposure to different environmental factors are becoming increasingly common. These studies are usually performed in umbilical cord blood. Since blood comprises multiple cell types with specific DNA methylation patterns, confounding caused by cellular heterogeneity is a major concern. This can be adjusted for using reference data consisting of DNA methylation signatures in cell types isolated from blood. However, the most commonly used reference… CONTINUE READING
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