Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

  title={Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells},
  author={Jose M. Polo and Susanna Liu and Maria E. Figueroa and Warakorn Kulalert and Sarah Eminli and Kah Yong Tan and Effie Apostolou and Matthias Stadtfeld and Yushan Li and Toshi Shioda and Sridaran Natesan and Amy J. Wagers and Ari M. Melnick and Todd Evans and Konrad Hochedlinger},
  journal={Nature Biotechnology},
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials… 

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