Cell type-dependent control of NF-Y activity by TGF-β

@article{Alabert2006CellTC,
  title={Cell type-dependent control of NF-Y activity by TGF-β},
  author={Constance Alabert and Lawrence W. Rogers and Laura Kahn and S Niellez and Patrick Fafet and Sylvain Cerulis and Jean Marie Blanchard and R. A. Hipskind and M L Vignais},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3387-3396}
}
Transforming growth factor β (TGF-β) is a pluripotent cytokine that regulates cell growth and differentiation in a cell type-dependent fashion. TGF-β exerts its effects through the activation of several signaling pathways. One involves membrane proximal events that lead to nuclear translocation of members of the Smad family of transcriptional regulators. TGF-β can also activate MAPK cascades. Here, we show that TGF-β induces nuclear translocation of the NF-YA subunit of the transcription factor… CONTINUE READING
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