Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2.

@article{Brown1994CellTA,
  title={Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2.},
  author={Shanna M Brown and J. Harland and Alasdair R. Maclean and J{\"u}rgen Podlech and J. B. Clements},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 9)},
  pages={2367-77}
}
The herpes simplex virus (HSV) gene RL1 encodes the protein ICP34.5, which is a specific neurovirulence factor. Null mutants in RL1 fail to replicate in the central nervous system of mice and are therefore totally non-neurovirulent. Additionally, they fail to replicate in neurons of the peripheral nervous system, although they are capable of establishing and reactivating from a latent infection. As the precise function of ICP34.5 in HSV-neuronal interactions is unknown, we have studied the role… CONTINUE READING