Cell-type-Specific Labeling of Synapses In Vivo through Synaptic Tagging with Recombination

@article{Chen2014CelltypeSpecificLO,
  title={Cell-type-Specific Labeling of Synapses In Vivo through Synaptic Tagging with Recombination},
  author={Yi Chen and Orkun Akin and Aljoscha Nern and C. Y. Kimberly Tsui and Matthew Y Pecot and S Lawrence Zipursky},
  journal={Neuron},
  year={2014},
  volume={81},
  pages={280-293}
}
The study of synaptic specificity and plasticity in the CNS is limited by the inability to efficiently visualize synapses in identified neurons using light microscopy. Here, we describe synaptic tagging with recombination (STaR), a method for labeling endogenous presynaptic and postsynaptic proteins in a cell-type-specific fashion. We modified genomic loci encoding synaptic proteins within bacterial artificial chromosomes such that these proteins, expressed at endogenous levels and with normal… CONTINUE READING
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