Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

@article{Bateup2008CellTR,
  title={Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs},
  author={Helen S Bateup and Per Svenningsson and Mahomi Kuroiwa and Shiaoching Gong and Akinori Nishi and Nathaniel Heintz and Paul Greengard},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={932-939}
}
DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs; however, these drugs are known to have opposing behavioral and clinical effects. We hypothesized that these drugs exert differential effects on striatonigral and striatopallidal neurons, which comprise distinct output pathways of the basal ganglia. To… CONTINUE READING
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