Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor.

@article{Fazel2005CellTP,
  title={Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor.},
  author={Shafie S Fazel and Liwen Chen and Richard D. Weisel and Denis Angoulvant and Charit K. Seneviratne and Amir Fazel and Phillip Cheung and Jason W. Lam and Paul W M Fedak and Terrence M. Yau and Ren-ke Li},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={130 5},
  pages={
          1310
        }
}
OBJECTIVE We hypothesized that implantation of adult mesenchymal stem cells after acute myocardial infarction mobilizes bone marrow precursor cells by activating the stem cell factor pathway, and that overdriving this pathway would enhance the beneficial effects of cell transplantation. METHODS After coronary ligation, medium, mesenchymal stem cells, or stem cell factor-overproducing mesenchymal stem cells were injected into the anterior left ventricle. Cells from beta-galactosidase… CONTINUE READING

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