Cell transformation results in the loss of the density-dependent translational regulation of the expression of fibroblast growth factor 2 isoforms.

@article{Galy1999CellTR,
  title={Cell transformation results in the loss of the density-dependent translational regulation of the expression of fibroblast growth factor 2 isoforms.},
  author={Bruno Galy and Arlett Maret and A. C. Prats and H. Prats},
  journal={Cancer research},
  year={1999},
  volume={59 1},
  pages={165-71}
}
Alternative initiation of translation at three CUG and one AUG start codons leads to the synthesis of four isoforms of fibroblast growth factor 2 (FGF-2) that have distinct intracellular localizations and affect the cell phenotype differently. We show here that the expression of FGF-2 CUG-initiated isoforms decreases in a cell-density-dependent manner in normal human skin fibroblasts (HSFs) concomitantly with the FGF-2 mRNA level. In contrast, CUG-initiated FGF-2 expression is constitutive in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 1996

Similar Papers

Loading similar papers…