Cell transformation induced by hepatitis C virus NS3 serine protease.

  title={Cell transformation induced by hepatitis C virus NS3 serine protease.},
  author={Romy Zemel and S Gerechet and Hagar Greif and Larisa Bachmatove and Yehudit Birk and Avi Golan-Goldhirsh and Margarita Kunin and Yevgeny Berdichevsky and Itai Benhar and Ran Tur-Kaspa},
  journal={Journal of viral hepatitis},
  volume={8 2},
Persistent infection with hepatitis C virus (HCV) may lead to hepatocellular carcinoma (HCC). It has been suggested that HCV-encoded proteins are directly involved in the tumorigenic process. The HCV nonstructural protein NS3 has been identified as a virus-encoded serine protease. To study whether HCV NS3 has oncogenic activity, nontumorigenic rat fibroblast (RF) cells were stably transfected with an expression vector containing cDNA for the NS3 serine protease (nucleotides 3356-4080). The NS3… CONTINUE READING
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