Cell transformation by the E7 oncoprotein of human papillomavirus type 16: interactions with nuclear and cytoplasmic target proteins.

@article{Zwerschke2000CellTB,
  title={Cell transformation by the E7 oncoprotein of human papillomavirus type 16: interactions with nuclear and cytoplasmic target proteins.},
  author={Werner Zwerschke and Pidder Jansen-Duerr},
  journal={Advances in cancer research},
  year={2000},
  volume={78},
  pages={1-29}
}
The E7 oncoprotein of human papillomavirus type 16 (HPV-16) has long been known as a potent immortalizing and transforming agent. However, the molecular mechanisms underlying cell transformation and immortalization by E7 remain largely unknown. It is believed that E7 exerts its oncogenic function at least in part by modulating cellular growth regulatory… CONTINUE READING