Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

@article{Li1994CellTB,
  title={Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.},
  author={Y T Li and Claudio Basilico and Alka Mansukhani},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 11},
  pages={7660-9}
}
Ligand-induced dimerization and transphosphorylation are thought to be important events by which receptor tyrosine kinases generate cellular signals. We have investigated the ability of signalling-defective, truncated fibroblast growth factor (FGF) receptors (FGFR-1 and FGFR-2) to block the FGF response in cells that express both types of endogenous FGF receptors. When these dominant negative receptors are expressed in NIH 3T3 cells transformed by the secreted FGF-4, the transformed properties… CONTINUE READING

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