Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics

@article{Zhang2017CelltocellVA,
  title={Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics},
  author={Qing Zhang and Federico Bassetti and Marco Gherardi and Marco Cosentino Lagomarsino},
  journal={Nucleic Acids Research},
  year={2017},
  volume={45},
  pages={8190 - 8198}
}
Abstract Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely available, the link between the key parameters and overall replication timing has not been addressed systematically. We use a combined analytical and computational approach to calculate how positions and strength of many origins lead to a given cell-to-cell… 

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