Cell-to-cell transmission of non-prion protein aggregates

@article{Lee2010CelltocellTO,
  title={Cell-to-cell transmission of non-prion protein aggregates},
  author={Seung-Jae Lee and Paula Desplats and Christina J Sigurdson and Igor F. Tsigelny and Eliezer Masliah},
  journal={Nature Reviews Neurology},
  year={2010},
  volume={6},
  pages={702-706}
}
Neurodegenerative disorders such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and Creutzfeldt–Jakob disease (CJD) are characterized by progressive accumulation of protein aggregates in selected brain regions. Protein misfolding and templated assembly into aggregates might result from an imbalance between protein synthesis, aggregation and clearance. Although protein misfolding and aggregation occur in most neurodegenerative disorders, the concept of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 104 extracted citations

Interaction between pathogenic proteins in neurodegenerative disorders

Journal of cellular and molecular medicine • 2012
View 8 Excerpts
Highly Influenced

Membrane Trafficking Illuminates a Path to Parkinson's Disease.

The Tohoku journal of experimental medicine • 2017
View 5 Excerpts
Highly Influenced

Towards translational therapies for multiple system atrophy

Progress in Neurobiology • 2014
View 6 Excerpts
Highly Influenced

Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders

TheScientificWorldJournal • 2011
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

Luk, C K.
Proc. Natl Acad. Sci. USA • 2009

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Induction of cerebral-amyloidosis : Intracerebral versus systemic A inoculation

Yvonne S. Eiselea, Tristan Bolmonta, +8 authors Mathias Juckera
2009

Similar Papers

Loading similar papers…