Cell-to-cell transmission of non-prion protein aggregates

  title={Cell-to-cell transmission of non-prion protein aggregates},
  author={Seung-Jae Lee and Paula Desplats and Christina J Sigurdson and Igor F. Tsigelny and Eliezer Masliah},
  journal={Nature Reviews Neurology},
Neurodegenerative disorders such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and Creutzfeldt–Jakob disease (CJD) are characterized by progressive accumulation of protein aggregates in selected brain regions. Protein misfolding and templated assembly into aggregates might result from an imbalance between protein synthesis, aggregation and clearance. Although protein misfolding and aggregation occur in most neurodegenerative disorders, the concept of… CONTINUE READING


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