Cell-to-cell transfer of HIV infection: implications for HIV viral persistence.

@article{Costiniuk2014CelltocellTO,
  title={Cell-to-cell transfer of HIV infection: implications for HIV viral persistence.},
  author={Cecilia T. Costiniuk and Mohammad-Ali Jenabian},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 11},
  pages={
          2346-55
        }
}
A major research priority for HIV eradication is the elucidation of the events involved in HIV reservoir establishment and persistence. Cell-to-cell transmission of HIV represents an important area of study as it allows for the infection of cell types which are not easily infected by HIV, leading to the establishment of long-lived viral reservoirs. This phenomenon enables HIV to escape elimination by the immune system. This process may also enable HIV to escape suppressive effects of anti… 
View on PubMed
doi.org
37 Citations
Background Citations
10

Figures from this paper

37 Citations

Citation Type

Citation Type

Mechanisms for Cell-to-Cell Transmission of HIV-1
TLDR
HIV-1 reuses its fusogenic capacity to provoke fusion between infected donor cells and target cells, and to form infected syncytia with high capacity of viral production and improved capacities of motility or survival, and could be involved in the establishment of persistent virus reservoirs in different host tissues.
Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.
TLDR
Research supporting the importance of anatomical tissues and other immune cells for HIV maintenance and expansion, including the central nervous system, lymph nodes, and macrophages is reviewed, and recent studies that have successfully used deep-sequencing strategies to uncover the complexity of HIV infection are cited.
HIV-1 hijacks the cell extracellular matrix to spread collectively and efficiently between T lymphocytes
TLDR
It is demonstrated that HIV-1 spreads between T lymphocytes in the form of viral particles colonies that are concentrated and sheltered in an extracellular matrix (ECM) lattice enabling their collective transmission upon cell contacts, and identified a novel fundamental role for collagen in this process.
Viral cell-to-cell spread: Conventional and non-conventional ways
The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
TLDR
The complex interaction between CCL2/CCR2 and HIV and the emerging therapeutic approaches based on the inhibition of this axis are discussed.
HCV spread kinetics reveal varying contributions of transmission modes to infection dynamics
TLDR
Combining in vitro experimental HCV spread data with a multi-scale mathematical model reveals synergistic effects between the two transmission modes and suggests that transmission modes might be optimized dependent on the environment, which could contribute to viral persistence.
Dynamics of HIV infection in lymphoid tissue network
TLDR
A new mathematical model is proposed that describes the spread of HIV infection throughout the lymphoid tissue network and implies that a portion of reservoir lymphoid tissues to which drug is not sufficiently delivered would inhibit HIV eradication despite of extensive drug injection.
Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era
TLDR
A comprehensive review of potent anti-HIV-1 peptides and proteins that reveal promising therapeutic activities and the inhibitory mechanisms of each therapeutic molecule in the different stages of the HIV-1 life cycle are discussed.
Current and Future Therapeutic Strategies for Lentiviral Eradication from Macrophage Reservoirs
AbstractMacrophages, one of the most abundant populations of leukocytes in the body, function as the first line of defense against pathogen invaders. Human Immunodeficiency virus 1 (HIV-1) remains to…
HIV-1 Infection of T Lymphocytes and Macrophages Affects Their Migration via Nef
TLDR
It is inferred that HIV-1 enhances virus spreading in confined environments by reducing T cells migration, and facilitates virus dissemination into different organs and tissues of the human body by enhancing macrophage mesenchymal migration.
...
1
2
3
4
...

References

SHOWING 1-10 OF 118 REFERENCES
Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
TLDR
A novel ex vivo model system that utilizes sealed human colonic mucosa explants is described and it is demonstrated that HIV-1-infected lymphocytes can transmit infection across the mucosa more efficiently than cell-free virus.
Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies.
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
TLDR
Examination of replication from cell-to-cell spread in the presence of clinical drug concentrations using a stochastic infection model finds that replication is intermittent, without substantial accumulation of mutations.
Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection
TLDR
It is suggested that cell-to-cell infection may explain the high copy numbers of proviruses found in infected cells in vivo and may provide a mechanism through which HIV preserves sequence heterogeneity in viral quasispecies through genetic complementation.
HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
TLDR
This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis.
Cell-to-Cell Transmission Can Overcome Multiple Donor and Target Cell Barriers Imposed on Cell-Free HIV
TLDR
It is demonstrated that HIV can spread by a cell-free pathway if all the steps of the viral replication cycle are efficiently supported in highly permissive cells, and that the donor and target cell types influence critically the extent by which cell-to-cell transmission can overcome each barrier.
Inefficient Human Immunodeficiency Virus Replication in Mobile Lymphocytes
TLDR
Results indicate that cell-to-cell transfer is the predominant mode of HIV spread and help to explain why this virus replicates so efficiently in lymphoid organs.
Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy
TLDR
It is demonstrated that a subset of non-T cells with NK markers are persistently infected and suggest that HIV infection of NK cells is important for virus persistence, and the properties of the virus reservoir in these cells should be considered in attempts to further optimize antiretroviral therapies.
Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues.
  • A. Haase
  • Biology
    Annual review of immunology
  • 1999
TLDR
A model of immune depletion and repopulation based on the limited regenerative capacity of the adult and the uncompensated losses of productively infected cells that treatment stems is presented, which predicts that immune regeneration will be slow, variable, and partial.
HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination
TLDR
Changes in the growth and differentiation process of HPCs may be involved in the generation of monocyte populations that are more susceptible and/or permissive to HIV-1, and have potentially altered trafficking profiles to several organs, including the CNS.
...
1
2
3
4
5
...