Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

@article{Dale2011CelltocellTO,
  title={Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.},
  author={Benjamin M. Dale and Gregory McNerney and Deanna L. Thompson and Wolfgang Hubner and Kevin de los Reyes and Frank S.-H. Chuang and Thomas Huser and Benjamin K Chen},
  journal={Cell host & microbe},
  year={2011},
  volume={10 6},
  pages={551-62}
}
HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus undergoes both maturation and viral membrane fusion. Following VS transfer, viral membrane fusion occurs with delayed kinetics and transferred virions display reduced sensitivity to patient antisera… CONTINUE READING
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