Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

  title={Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy},
  author={Alex Sigal and Jocelyn T. Kim and Alejandro Benjamin Balazs and Erez Dekel and Avi E. Mayo and Ron Milo and David Baltimore},
Latency and ongoing replication have both been proposed to explain the drug-insensitive human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy. Here we explore a novel mechanism for ongoing HIV replication in the face of antiretroviral drugs. We propose a model whereby multiple infections per cell lead to reduced sensitivity to drugs without requiring drug-resistant mutations, and experimentally validate the model using multiple infections per cell by cell-free… 

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