Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

@article{Sigal2011CelltocellSO,
  title={Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy},
  author={A. Sigal and Jocelyn T. Kim and A. Balazs and E. Dekel and Avi E. Mayo and R. Milo and D. Baltimore},
  journal={Nature},
  year={2011},
  volume={477},
  pages={95-98}
}
Latency and ongoing replication have both been proposed to explain the drug-insensitive human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy. Here we explore a novel mechanism for ongoing HIV replication in the face of antiretroviral drugs. We propose a model whereby multiple infections per cell lead to reduced sensitivity to drugs without requiring drug-resistant mutations, and experimentally validate the model using multiple infections per cell by cell-free… Expand
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