Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

@inproceedings{Franzetti2017CelltocellHO,
  title={Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells},
  author={G-A Franzetti and Karine Laud-Duval and W van der Ent and A Brisac and Marie Irondelle and S{\'e}bastien Aubert and Uta Dirksen and Corinne Bouvier and Gonzague de Pinieux and Ewa Snaar-Jagalska and Philippe Chavrier and Olivier Delattre},
  booktitle={Oncogene},
  year={2017}
}
Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix adhesion. These changes are associated with a dramatic increase of in vivo cell migration and invasion potential. Importantly, EWSR1-FLI1 expression, evaluated by single-cell RT… CONTINUE READING
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