Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures.

@article{Luther2005CelltocellCI,
  title={Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures.},
  author={Melanie J Luther and Emma J Davies and Dany Muller and Moira Harrison and Adrian J. Bone and Shanta J Persaud and Peter Martin Jones},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 3},
  pages={E502-9}
}
Cell-to-cell interactions play an important role in the development and maintenance of the beta-cell phenotype. Here, we have investigated whether E-cadherin plays a role in regulating the growth of insulin-secreting MIN6 cells configured as three-dimensional islet-like clusters (pseudoislets). Pseudoislets form by cell aggregation rather than by proliferation from individual cells and attain the size of primary mouse islets after approximately 7 days of maintenance in culture. E-cadherin is… CONTINUE READING
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