Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4.

Abstract

OBJECTIVES HIV reservoir in the brain represents a major barrier for curing HIV infection. As the most abundant, long-lived cell type, astrocytes play a critical role in maintaining the reservoir; however, the mechanism of infection remains unknown. Here, we determine how viral transmission occurs from HIV-infected lymphocytes to astrocytes by cell-to-cell… (More)
DOI: 10.1097/QAD.0000000000000605

Topics

5 Figures and Tables

Cite this paper

@article{Li2015CelltocellCF, title={Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4.}, author={Guan-Han Li and C Christian Anderson and Laura B. Jaeger and Thao D{\^o} and Eugene O. Major and Avindra Nath}, journal={AIDS}, year={2015}, volume={29 7}, pages={755-66} }