Cell-to-cell communication: current views and future perspectives

  title={Cell-to-cell communication: current views and future perspectives},
  author={Hans-Hermann Gerdes and Rainer Pepperkok},
  journal={Cell and Tissue Research},
Multicellular organisms rely on complex and tightly regulated communication between individual cells embedded in a dense extracellular matrix. Through the course of evolution, diverse mechanisms underlying this communication have appeared. These include communication via direct cell–to-cell contact (e.g., Delta/Notch signalling), the release of soluble factors (e.g., hormones, cytokines) that activate target cells locally or distantly through surface receptors and the direct transfer of signals… 

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