Cell-to-Cell Signaling Influences the Fate of Prostate Cancer Stem Cells and Their Potential to Generate More Aggressive Tumors

@inproceedings{Salvatori2012CelltoCellSI,
  title={Cell-to-Cell Signaling Influences the Fate of Prostate Cancer Stem Cells and Their Potential to Generate More Aggressive Tumors},
  author={Luisa Salvatori and Francesca Caporuscio and Alessandra Verdina and Giuseppe Starace and Stefania Crispi and Maria Rita Nicotra and Andrea G. Russo and Raffaele Adolfo Calogero and Emanuela Morgante and Pier Giorgio Natali and Matteo Antonio Russo and Elisa Petrangeli},
  booktitle={PloS one},
  year={2012}
}
An increasing number of malignancies has been shown to be initiated and propelled by small subpopulations of cancer stem cells (CSC). However, whether tumor aggressiveness is driven by CSC and by what extent this property may be relevant within the tumor mass is still unsettled. To address this issue, we isolated a rare tumor cell population on the basis of its CD44(+)CD24(-) phenotype from the human androgen-independent prostate carcinoma cell line DU145 and established its CSC properties. The… CONTINUE READING
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