Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

  title={Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity},
  author={Albert Herms and Marta Bosch and Nicholas Ariotti and Babu J. N. Reddy and Alba Fajardo and Andrea Fern{\'a}ndez-Vidal and Anna {\'A}lvarez-Guaita and Manuel Alejandro Fern{\'a}ndez-Rojo and Carles Rentero and Francesc Tebar and Carlos Enrich and Mar{\'i}a-Isabel Geli and Robert G. Parton and Steven P. Gross and Albert Pol},
  journal={Current Biology},
Lipid droplets (LDs) are dynamic organelles that collect, store, and supply lipids [1]. LDs have a central role in the exchange of lipids occurring between the cell and the environment and provide cells with substrates for energy metabolism, membrane synthesis, and production of lipid-derived molecules such as lipoproteins or hormones. However, lipid-derived metabolites also cause progressive lipotoxicity [2], accumulation of reactive oxygen species (ROS), endoplasmic reticulum stress… CONTINUE READING


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Publications referenced by this paper.
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Proceedings of the National Academy of Sciences of the United States of America • 2011
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