Cell therapy with adipose tissue-derived stem/stromal cells for elastase-induced pulmonary emphysema in rats.

@article{Furuya2012CellTW,
  title={Cell therapy with adipose tissue-derived stem/stromal cells for elastase-induced pulmonary emphysema in rats.},
  author={Naoki Furuya and Mitsuko Takenaga and Yuki Ohta and Yukie Tokura and Akemi Hamaguchi and Aya Sakamaki and Hirotaka Kida and Hiroshi Handa and Hiroki Nishine and Masamichi Mineshita and Teruomi Miyazawa},
  journal={Regenerative medicine},
  year={2012},
  volume={7 4},
  pages={503-12}
}
AIMS The purpose of this study was to elucidate the mechanism underlying the effects of adipose tissue-derived stem/stromal cell (ASC) transplantation on porcine pancreatic elastase-induced emphysema. MATERIALS & METHODS ASCs (2.5 × 10(6)) were transplanted into pancreatic elastase (250 U/kg)-treated rats, after which gas exchange and growth factor/cytokine levels in lung tissue were determined. RESULTS ASC transplantation restored pulmonary function (arterial oxygen tension and alveolar… CONTINUE READING