Cell swelling, seizures and spreading depression: an impedance study.

@article{Olsson2006CellSS,
  title={Cell swelling, seizures and spreading depression: an impedance study.},
  author={Torsten Olsson and Marita Broberg and Kenneth J. Pope and Angus Wallace and Lorraine Mackenzie and Fredrik Blomstrand and Michael Nilsson and John O. Willoughby},
  journal={Neuroscience},
  year={2006},
  volume={140 2},
  pages={505-15}
}
The cellular processes that take place during the transition from pre-seizure state to seizure remain to be defined. In this study in awake, paralyzed rats, we used an electrical impedance measure of changes in extra-cellular intracranial volume to estimate changes in cell size in acute models of epilepsy. Animals were prepared with extradural electroencephalographic (EEG)/impedance electrodes and a venous catheter. On a subsequent day, animals were paralyzed, ventilated and treated with… CONTINUE READING