Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

@article{Kensler2007CellSR,
  title={Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.},
  author={Thomas W Kensler and Nobunao Wakabayashi and Shyam Biswal},
  journal={Annual review of pharmacology and toxicology},
  year={2007},
  volume={47},
  pages={
          89-116
        }
}
Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway. These mice are more sensitive to the hepatic, pulmonary, ovarian, and neurotoxic consequences of acute exposures to environmental agents and drugs, inflammatory stresses, as well as chronic exposures to cigarette smoke and other carcinogens. Under quiescent conditions, the… CONTINUE READING

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