Cell-survival probability at large doses: an alternative to the linear-quadratic model.

@article{Hanin2010CellsurvivalPA,
title={Cell-survival probability at large doses: an alternative to the linear-quadratic model.},
author={Leonid Hanin and Marco Zaider},
journal={Physics in medicine and biology},
year={2010},
volume={55 16},
pages={4687-702}
}

A model of irradiated cell survival based on rigorous accounting of microdosimetric effects is developed. The model does not assume that the distribution of lesions is Poisson and is applicable to low, intermediate and high acute doses of low or high LET radiation. For small doses, the model produces the linear-quadratic (LQ) model. However, for high doses the best-fitting LQ model grossly underestimates cell survival. The same is also true for the conventional LQ model, only more so. It is… CONTINUE READING