Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review).

@article{Franken2013CellSA,
  title={Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review).},
  author={Nicolaas A. P. Franken and Arlene L Oei and H. Petra Kok and Hans M. Rodermond and Peter Sminia and Johannes Crezee and Lukas J. A. Stalpers and Gerrit W. Barendsen},
  journal={International journal of oncology},
  year={2013},
  volume={42 5},
  pages={1501-15}
}
The linear-quadratic model (LQ model) provides a biologically plausible and experimentally established method to quantitatively describe the dose-response to irradiation in terms of clonogenic survival. In the basic LQ formula, the clonogenic surviving fraction Sd/S₀ following a radiation dose d (Gy) is described by an inverse exponential approximation: Sd/S₀ = e-(αd+βd²), wherein α and β are experimentally derived parameters for the linear and quadratic terms, respectively. Radiation is often… CONTINUE READING
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