Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation

  title={Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation},
  author={Richard A Majack and L. Veatch Goodman and Vishva M. Dixit},
  journal={The Journal of Cell Biology},
  pages={415 - 422}
Thrombospondin (TS) is an extracellular glycoprotein whose synthesis and secretion by vascular smooth muscle cells (SMC) is regulated by platelet-derived growth factor. We have used a panel of five monoclonal antibodies against TS to determine an essential role for thrombospondin in the proliferation of cultured rat aortic SMC. All five monoclonal antibodies inhibited SMC growth in 3-d and extended cell number assays; the growth inhibition was specific for anti-TS IgG. The effects of one… CONTINUE READING


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