Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter.

@article{Zhang2005CellST,
  title={Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter.},
  author={Zhaoxia Zhang and Yu-Yu Liu and Sissy M. Jhiang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 11},
  pages={6131-40}
}
CONTEXT The Na+/I- symporter (NIS) has been proposed to serve as an imaging reporter gene to optimize vector delivery, monitor therapeutic gene expression, and map the tissue/organ sites of repopulated progenitor cells in vivo. In addition, NIS can serve as a therapeutic gene to facilitate targeted radionuclide therapy for various cancers. OBJECTIVE It was reported that rat NIS (rNIS) confers higher radioactive iodide uptake (RAIU) activity than human NIS (hNIS). We aim to investigate the… CONTINUE READING