Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity.

@article{Llamas2014CellsurfaceSI,
  title={Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity.},
  author={M. Llamas and F. Imperi and P. Visca and I. Lamont},
  journal={FEMS microbiology reviews},
  year={2014},
  volume={38 4},
  pages={
          569-97
        }
}
Membrane-spanning signaling pathways enable bacteria to alter gene expression in response to extracytoplasmic stimuli. Many such pathways are cell-surface signaling (CSS) systems, which are tripartite molecular devices that allow Gram-negative bacteria to transduce an extracellular stimulus into a coordinated transcriptional response. Typically, CSS systems are composed of the following: (1) an outer membrane receptor, which senses the extracellular stimulus; (2) a cytoplasmic membrane-spanning… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Processing of cell-surface signalling anti-sigma factors prior to signal recognition is a conserved autoproteolytic mechanism that produces two functional domains.
TLDR
The results indicate that CSS regulation can occur through both complete and initially processed anti-sigma factors that are not cleaved prior to signal perception. Expand
Pseudomonas aeruginosa possesses three distinct systems for sensing and using the host molecule heme.
TLDR
It is shown that the Has and Hxu systems are functional signal transduction pathways of the cell-surface signaling class and the mechanism triggering the activation of these signaling systems is reported, highlighting the importance of heme signaling for this pathogen. Expand
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TLDR
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TLDR
Proteomic analysis indicates for the first time that in pathogenic P. fluorescens, iron affects the expression of a large number of proteins including those that are involved in host infection. Expand
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