Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.

@article{Menard2003CellSR,
  title={Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.},
  author={Raymond E Menard and Raymond R. Mattingly},
  journal={Cellular signalling},
  year={2003},
  volume={15 12},
  pages={1099-109}
}
p21-activated kinases (PAKs) were the first identified mammalian members of a growing family of Ste20-like serine-threonine protein kinases. In this study, we show that PAK1 can be stimulated by carbachol, lysophosphatidic acid (LPA), epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) by multiple independent and overlapping pathways. Dominant-negative Ras, Rac, and Cdc42 inhibited PAK1 activation by all of these agonists, while active Rac1 and Cdc42 were sufficient to… CONTINUE READING
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