Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide.

@article{Zai1999CellsurfacePD,
  title={Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide.},
  author={Adrian H. Zai and M Audrey Rudd and Anne Ward Scribner and Joseph Loscalzo},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 3},
  pages={393-9}
}
Since thiols can undergo nitrosation and the cell membrane is rich in thiol-containing proteins, we considered the possibility that membrane surface thiols may regulate cellular entry of NO. Recently, protein disulfide isomerase (PDI), a protein that catalyzes thio-disulfide exchange reactions, has been found on the cell-surface membrane. We hypothesized… CONTINUE READING