Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines.

@article{Herst2007CellSO,
  title={Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines.},
  author={Patries M Herst and Michael V Berridge},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1767 2},
  pages={
          170-7
        }
}
Oxygen consumption for bioenergetic purposes has long been thought to be the prerogative of mitochondria. Nevertheless, mitochondrial gene knockout (rho(0)) cells that are defective in mitochondrial respiration require oxygen for growth and consume oxygen at the cell surface via trans-plasma membrane electron transport (tPMET). This raises the possibility that cell surface oxygen consumption may support glycolytic energy metabolism by reoxidising cytosolic NADH to facilitate continued… CONTINUE READING

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