Cell surface localisation and stability of uvomorulin during early mouse development.

@article{Clayton1993CellSL,
  title={Cell surface localisation and stability of uvomorulin during early mouse development.},
  author={Lesley Clayton and Sian Stinchcombe and Martin J. Johnson},
  journal={Zygote},
  year={1993},
  volume={1 4},
  pages={333-44}
}
We have examined immunocytochemically the subcellular distribution of the cell adhesion molecule uvomorulin in cleavage stage mouse embryos using conventional and confocal microscopy, under a range of detergent extraction and fixation regimes. Only traces of uvomorulin were detectable on the surface of unfertilised oocytes, whereas between 6 and 11 h after activation detergent-resistant surface expression was evident. This shift correlates with previously demonstrated changes in the pattern of… CONTINUE READING