Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin.

@article{Jasuja2004CellsurfaceHS,
  title={Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin.},
  author={Reema Jasuja and Benjamin L Allen and William N. Pappano and Alan C. Rapraeger and Daniel S. Greenspan},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 49},
  pages={51289-97}
}
Signaling by bone morphogenetic proteins (BMPs) plays a central role in early embryonic patterning, organogenesis, and homeostasis in a broad range of species. Chordin, an extracellular antagonist of BMP signaling, is thought to readily diffuse in tissues, thus forming gradients of BMP inhibition that result in reciprocal gradients of BMP signaling. The latter determine cell fates along the embryonic dorsoventral axis. The secreted protein Twisted Gastrulation (TSG) is thought to help shape BMP… CONTINUE READING
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HSPGs Regulate Chordin Function, Uptake, and Diffusion 51297 at U nirsity of M icgan, on F ebuary 16

  • J. Larrain, C. Brown, E. M. De Robertis
  • EMBO Rep. 4,
  • 2003
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