Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.

@article{Shimokawa2011CellSH,
  title={Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo.},
  author={Kayo Shimokawa and Chiharu Kimura-Yoshida and Naoko Nagai and Kazuhiro Mukai and Kazumi Matsubara and Hideto Watanabe and Yoichi Matsuda and Kyoko Mochida and Isao Matsuo},
  journal={Developmental cell},
  year={2011},
  volume={21 2},
  pages={257-72}
}
Heparan sulfate (HS) proteoglycans modulate the activity of multiple growth factors on the cell surface and extracellular matrix. However, it remains unclear how the HS chains control the movement and reception of growth factors into targeted receiving cells during mammalian morphogenetic processes. Here, we found that HS-deficient Ext2 null mutant mouse embryos fail to respond to fibroblast growth factor (FGF) signaling. Marker expression analyses revealed that cell surface-tethered HS chains… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli

Proceedings of the National Academy of Sciences of the United States of America • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Shaping morphogen gradients by proteoglycans.

Cold Spring Harbor perspectives in biology • 2009
View 20 Excerpts
Highly Influenced

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 8 Excerpts
Highly Influenced

Manipulating of the Mouse Embryo

A. Nagy, M. Gertsenstein, K. Vintersten, R. Behringer
A Laboratory Manual, • 2003
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…