Cell surface glypicans are low-affinity endostatin receptors.

  title={Cell surface glypicans are low-affinity endostatin receptors.},
  author={Siddharth Karumanchi and Vivek Jha and Ramani Ramchandran and Anil Karihaloo and Leonidas Tsiokas and Barden Chan and Mohanraj Dhanabal and Jun-ichi Hanai and Ganesh Venkataraman and Zachary H. Shriver and Nishla Keiser and Raghu Kalluri and Huiquing Zeng and Debdyuti Mukhopadhyay and Ruo L Chen and Arthur D. Lander and Katsunobu Hagihara and Yuki Yamaguchi and Ram Sasisekharan and Lewis Cantley and Vikas P Sukhatme},
  journal={Molecular cell},
  volume={7 4},
Endostatin, a collagen XVIII fragment, is a potent anti-angiogenic protein. We sought to identify its endothelial cell surface receptor(s). Alkaline phosphatase- tagged endostatin bound endothelial cells revealing two binding affinities. Expression cloning identified glypican, a cell surface proteoglycan as the lower-affinity receptor. Biochemical and genetic studies indicated that glypicans' heparan sulfate glycosaminoglycans were critical for endostatin binding. Furthermore, endostatin… CONTINUE READING


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