Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer.

@article{Gabius2006CellSG,
  title={Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer.},
  author={Hans-Joachim Gabius},
  journal={Critical reviews in immunology},
  year={2006},
  volume={26 1},
  pages={43-79}
}
Calculations of the coding capacity of biomolecules come up with the striking result that carbohydrates excel nucleotides and amino acids by far in this respect. Consequently, glycans are ideally suited to equip cell surfaces with a maximum of signals in a minimum of space and form the cellular glycome. The ensuing concept of the sugar code interprets glycans as a platform for encoding messages and shifts in the glycome as a means to swiftly add/remove signals. Next, it implies the presence of… CONTINUE READING

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