Cell surface expression of lysosome-associated membrane protein-2 (lamp2) and CD63 as markers of in vivo platelet activation in malignancy.

@article{Kannan1995CellSE,
  title={Cell surface expression of lysosome-associated membrane protein-2 (lamp2) and CD63 as markers of in vivo platelet activation in malignancy.},
  author={Krishnaswamy Kannan and Stephen G Divers and Aubrey Lurie and Robert P Chervenak and Minoru Fukuda and Randall F. Holcombe},
  journal={European journal of haematology},
  year={1995},
  volume={55 3},
  pages={145-51}
}
Platelets may become activated in vivo in a number of prethrombotic conditions including cancer. In the present study, cell surface expression of lysosome-associated membrane protein-2 (lamp2) and CD63 (lamp3) were examined by flow cytometry in 15 healthy volunteers and 5 patients with metastatic cancer to determine their utility as markers of in vivo platelet activation. Unstimulated platelets from controls had low levels of lamp2 expression, in contrast to cancer patients, who had… CONTINUE READING

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