Cell surface engineering by a modified Staudinger reaction.

@article{Saxon2000CellSE,
  title={Cell surface engineering by a modified Staudinger reaction.},
  author={Eliana Saxon and Carolyn R Bertozzi},
  journal={Science},
  year={2000},
  volume={287 5460},
  pages={2007-10}
}
Selective chemical reactions enacted within a cellular environment can be powerful tools for elucidating biological processes or engineering novel interactions. A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is presented. A ligation modeled after the Staudinger reaction forms an amide bond by coupling of an azide and a specifically engineered triarylphosphine. Both reactive partners are abiotic… CONTINUE READING
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