Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy

Abstract

Prodrug conversion is a promising approach to cytotoxic gene therapy if an efficient transfer of the generated drug to adjacent cells can be achieved. To maximize the efficacy of this strategy we sought to develop a system that is based on a human enzyme, acts extracellularly yet in close vicinity of the transduced cell and can be used with multiple… (More)
DOI: 10.1038/sj.gt.3301474

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Cite this paper

@article{Heine2001CellSD, title={Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy}, author={Daniel J Heine and R. M{\"u}ller and Sabine Br{\"u}sselbach}, journal={Gene Therapy}, year={2001}, volume={8}, pages={1005-1010} }