Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli.

@article{CortesPerez2005CellsurfaceDO,
  title={Cell-surface display of E7 antigen from human papillomavirus type-16 in Lactococcus lactis and in Lactobacillus plantarum using a new cell-wall anchor from lactobacilli.},
  author={Naima G. Cortes-Perez and Vasco Azevedo and Juan Manuel Alcocer-Gonz{\'a}lez and Cristina na Rodr{\'i}guez-Padilla and Reyes Silvestre Tamez-Guerra and G{\'e}rard Corthier and Alexandra Gruss and Philippe Langella and Luis G Berm{\'u}dez-Humar{\'a}n},
  journal={Journal of drug targeting},
  year={2005},
  volume={13 2},
  pages={
          89-98
        }
}
The human papillomavirus type-16 (HPV-16) E7 protein is considered a major viral oncoprotein involved in cervical cancer (CxCa) and a potential candidate for the development of a vaccine against this neoplasia. Here, two lactic acid bacteria (the model one Lactococcus lactis and a probiotic one Lactobacillus plantarum) were engineered to deliver an E7 mutant protein (E7mm), which has a reduced transforming activity and consequently, could fit better to therapeutic use in humans than the native… CONTINUE READING
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