Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures.

@article{Ferguson1988CellsurfaceAO,
  title={Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures.},
  author={Michelle Ferguson and Alan F. Williams},
  journal={Annual review of biochemistry},
  year={1988},
  volume={57},
  pages={285-320}
}
A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence that signals attachment of a glycosyl-phosphatidylinositol anchor at a COOH-terminal residue that is newly formed by cleavage of the signaling sequence. This class includes a wide diversity of protein types from eukaryotes at many stages of evolution. The structures of the glycosyl-phosphatidylinositol anchors are being resolved, but their functions aside from membrane… CONTINUE READING

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