Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells.

@article{Corts2002CellSC,
  title={Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells.},
  author={Mar{\'i}a Jos{\'e} Cort{\'e}s and Flossie Wong-Staal and Juan Lama},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 3},
  pages={1770-9}
}
The CD4 protein is required for the entry of human immunodeficiency virus (HIV) into target cells. Upon expression of the viral genome, three HIV-1 gene products participate in the removal of the primary viral receptor from the cell surface. To investigate the role of surface-CD4 in HIV replication, we have created a set of Jurkat cell lines which constitutively express surface levels of CD4 comparable to those found in peripheral blood lymphocytes and monocytes. Expression of low levels of CD4… CONTINUE READING

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