Cell suicide for beginners

@article{Raff1998CellSF,
  title={Cell suicide for beginners},
  author={Martin C. Raff},
  journal={Nature},
  year={1998},
  volume={396},
  pages={119-119}
}
  • M. Raff
  • Published 12 November 1998
  • Biology, Medicine
  • Nature
The ability to commit suicide is a fundamental property of animal cells. This overview considers recent progress in understanding the nature of the suicide process and how it is controlled. 
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For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells, so dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells.
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A caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD) have now been identified in the cytoplasmic fraction of mouse lymphoma cells and seems to function as a chaperone for CAD during its synthesis, remaining complexed with CAD to inhibit its DNase activity.
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