Cell stress-associated caspase activation: intrinsically complex?

  title={Cell stress-associated caspase activation: intrinsically complex?},
  author={Emma M. Creagh and Seamus J. Martin},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2003 175},
Apoptosis, or programmed cell death, involves the activation of the caspases, a family of cysteine proteases that coordinate the process of cellular demolition. In the intrinsic--or mitochondrial--pathway to apoptosis, which is initiated in response to various types of cell stress, the prevailing view is that caspases become activated in a structure called the apoptosome after cytochrome c is released from the mitochondria. However, recent research challenges this view and suggests that one or… CONTINUE READING

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