Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.

@article{CavalcantiAdam2007CellSA,
  title={Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.},
  author={Elisabetta Ada Cavalcanti-Adam and Tova Volberg and Alexandre Micoulet and Horst Kessler and Benjamin Geiger and Joachim P Spatz},
  journal={Biophysical journal},
  year={2007},
  volume={92 8},
  pages={2964-74}
}
Integrin-mediated adhesion is regulated by multiple features of the adhesive surface, including its chemical composition, topography, and physical properties. In this study we investigated integrin lateral clustering, as a mechanism to control integrin functions, by characterizing the effect of nanoscale variations in the spacing between adhesive RGD ligands on cell spreading, migration, and focal adhesion dynamics. For this purpose, we used nanopatterned surfaces, containing RGD… CONTINUE READING
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