Cell-specific transcription of leukotriene C(4) synthase involves a Kruppel-like transcription factor and Sp1.

@article{Zhao2000CellspecificTO,
  title={Cell-specific transcription of leukotriene C(4) synthase involves a Kruppel-like transcription factor and Sp1.},
  author={Jie Zhao and K Frank Austen and Bing K. Lam},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 12},
  pages={8903-10}
}
Leukotriene C(4) synthase (LTC(4)S) is responsible for the biosynthesis of cysteinyl leukotrienes that participate in allergic and asthmatic inflammation. We analyzed 2.1 kilobases of the 5'-flanking region of the human LTC(4)S gene, which contains three DNase I hypersensitivity sites, for its transcriptional activity when fused to a promoterless and enhancerless luciferase gene. Deletion analysis revealed a nonspecific basal promoter region between nucleotides -122 and -56 upstream of the… CONTINUE READING

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