Cell-specific responses to loss of cyclin-dependent kinases

  title={Cell-specific responses to loss of cyclin-dependent kinases},
  author={Cyril Berthet and Philipp Kaldis},
Inactivation of cyclin-dependent kinases (Cdks) and/or cyclins in mice has changed our view of cell cycle regulation. In general, cells are far more resistant to the loss of Cdks than originally anticipated, suggesting widespread compensation among the Cdks. Early embryonic cells are, so far, not sensitive to the lack of multiple Cdks or cyclins. In contrast, differentiated cells are more dependent on Cdk/cyclin complexes and the functional redundancy is more limited. Our challenge is to better… CONTINUE READING

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