Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

@article{Kelly1983CellspecificRO,
  title={Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.},
  author={Kathleen Kelly and Brent H Cochran and Charles Dean Stiles and Philip Leder},
  journal={Cell},
  year={1983},
  volume={35 3 Pt 2},
  pages={603-10}
}
We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner. Specifically, agents that initiate the first phase of a proliferative response in lymphocytes (lipopolysaccharide or Concanavalin A) and fibroblasts (platelet-derived growth factor) induce c-myc mRNA. Within one to three hr after the addition of these mitogens to the appropriate cells, c-myc mRNA concentration is increased between 10- and 40-fold. This induction of c-myc mRNA… CONTINUE READING